Sameh Mohamed Abouzeid
Theodor Bilharz Research Institute
Title: Hormonal therapy in women: Renal adverse effects
Biography
Biography: Sameh Mohamed Abouzeid
Abstract
Chronic Kidney Disease (CKD) is commonly associated with menstrual disorders, infertility, and premature menopause.
Nephrologists are often considered as the primary care providers by their patients, but perceptions of nephrologists on
management of these issues are currently unknown. Studies proved there was a high level of uncertainty among Nephrologists
with regard to the role of Hormonal Therapy (HT) in women with CKD. Primary ovarian function appears to be preserved in the
setting of CKD, ovulatory and menstrual irregularities observed in the CKD are likely to be the consequence of hypothalamic
and pituitary, rather than ovarian. Increases renal tubular responsiveness to changes in sodium intake leading to an increased
GFR and filtration fraction, an increase in renal nitric oxide and an increase in Renin–Angiotensin Activity (RAS), which has
been linked to a greater risk of diabetic nephropathy while hormonal replacement therapy was associated with a 19% reduction
in ACR (P=0.008) and an odds ratio of 0.67 (95% confidence interval, 0.43 to 1.01; P=0.06).